Discovery Projects - Grant ID: DP160101429

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160101429

Funding Status
Closed

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Funded Activity Summary

Escaping Bio-Assay Guided Isolation: Nature's Tools for Chemical Biology. The project aims to transform the approach to identify novel biologically active compounds that occur in nature. For decades, natural product chemistry has centred on bio-assay guided isolation, but it has become increasingly difficult to isolate novel compounds. While de-replication strategies detect the presence of known compounds using databases, more impact would be achieved by directly detecting novel compounds. Nuclear magnetic resonance (NMR) spectroscopy detects every molecule that has a proton and is quantitative. This project plans to develop a NMR technique to escape bio-assay guided isolation by analysing a fraction library. Biotechnology innovation is dependent on novel compounds to provide new products. Replacing ‘grind and find’ with a technique that never lies would be transformational.

Funded Activity Details

Start Date: 01-01-2016

End Date: 31-12-2021

Funding Scheme: Discovery Projects

Funding Amount: $493,300.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Natural Products Chemistry | Medicinal and Biomolecular Chemistry | Biologically Active Molecules | Medicinal and Biomolecular Chemistry not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences |

Other Keywords

Biologically Active Molecules | Expanding Knowledge in the Chemical Sciences | Medicinal and Biomolecular Chemistry | Medicinal and Biomolecular Chemistry not elsewhere classified | Natural Products Chemistry

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