Discovery Projects - Grant ID: DP160101343

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160101343

Funding Status
Closed

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Funded Activity Summary

The role of X-chromosome inactivation in quantitative trait variation. This project aims to develop methods and software that can be applied to genetic and genomic studies in animal breeding, wildlife protection, and humans. X-chromosome inactivation (XCI) is an important biological phenomenon but its effect on quantitative trait variation remains largely unknown. This project aims to develop novel statistical methods to estimate the X-linked genetic variance and the proportion that escapes XCI, and identify trait-associated genetic variants affected and not affected by XCI. The methods would then be applied to large datasets from genome-wide association studies for a large number of traits. Project outcomes may enable us to better understand the role of XCI in quantitative trait variation and gene expression in humans and animals.

Funded Activity Details

Start Date: 01-03-2016

End Date: 31-12-2019

Funding Scheme: Discovery Projects

Funding Amount: $319,800.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression (incl. Microarray and other genome-wide approaches) | Population, Ecological and Evolutionary Genetics | Genetics | Quantitative Genetics (incl. Disease and Trait Mapping Genetics)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Expanding Knowledge in the Biological Sciences | Gene Expression (incl. Microarray and other genome-wide approaches) | Genetics | Population, Ecological and Evolutionary Genetics | Quantitative Genetics (incl. Disease and Trait Mapping Genetics)

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