Discovery Projects - Grant ID: DP160101324

Funded Activity Summary

New peptide ligation technology for the rapid assembly of modified proteins. The project aims to develop novel technologies to enable the synthesis of modified proteins that are of widespread biological and therapeutic interest. More than 70 per cent of all human proteins are modified with a range of functionalities after translation from the ribosome. Although these modifications are of crucial importance for biological activity, characterising the effect of a given modification on function is difficult due to problems in obtaining the protein in pure form. The goal of this project is to develop a peptide ligation methodology to access pure modified proteins in a rapid manner through the exploitation of a new reaction recently discovered in our laboratory. The project plans to explore the scope and mechanism of the new reaction as well as its application in the total chemical synthesis and structure-function studies of important modified proteins.

Funded Activity Details

Start Date: 05-01-2016

End Date: 31-12-2018

Funding Scheme: Discovery Projects

Funding Amount: $452,738.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Organic Chemistry | Organic Chemical Synthesis | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biologically Active Molecules | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Organic Chemical Synthesis | Organic Chemistry | Proteins and Peptides

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