Discovery Projects - Grant ID: DP160101043

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160101043

Funding Status
Closed

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Funded Activity Summary

Novel cysteine-rich conotoxin frameworks from Australian cone snails. This project aims to discover conotoxins that are potential drug leads or useful pharmacological tools. It aims to increase both the discovery of novel conotoxin cysteine-rich frameworks through integrated transcriptomics and proteomics (venomics), conotoxin synthesis and 3-D structure determination, and to generate conotoxin disulfide bond mimetics and conotoxin dendrimers to increase stability, potency and selectivity. The work is designed to be based on a venomics platforms to accelerate conotoxin framework discovery while using novel mimetics and dendrimeric constructs to improve their biophysical properties. The expected outcomes include an expansion of novel conotoxin sequences and novel frameworks to generate lead molecules for potential development.

Funded Activity Details

Start Date: 01-01-2016

End Date: 08-07-2019

Funding Scheme: Discovery Projects

Funding Amount: $210,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biologically Active Molecules | Characterisation of Biological Macromolecules | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Medicinal and Biomolecular Chemistry | Proteins and Peptides

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