Discovery Projects - Grant ID: DP160100325

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160100325

Funding Status
Closed

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Funded Activity Summary

The role of copper in the early ubiquitination pathway. This project aims to explore the role of copper in ageing and protein turnover. The removal of damaged or excess proteins is achieved by ubiquitin-tagging in all kingdoms of life. It has recently been observed that one of the earliest steps of this process appears to be driven by copper. This project aims to elaborate the precise biochemical mechanisms by which copper regulates this important tagging and protein turnover system. It proposes to characterise the structure and function of a newly identified copper-dependent form of cell enzyme which could be involved in amplifying ubiquitin-tagged protein breakdown. Copper is essential for life in all domains. Identifying copper as a major regulator in protein clearance is important in understanding this fundamental biological machinery.

Funded Activity Details

Start Date: 04-01-2016

End Date: 03-01-2019

Funding Scheme: Discovery Projects

Funding Amount: $348,500.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Inorganic Chemistry | Bioinorganic Chemistry | Cell Metabolism | Cell Neurochemistry

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in Technology |

Other Keywords

Bioinorganic Chemistry | Cell Metabolism | Cell Neurochemistry | Expanding Knowledge in Technology | Expanding Knowledge in the Biological Sciences | Inorganic Chemistry

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