Discovery Projects - Grant ID: DP160100011

Funded Activity Summary

Defining systems that clear dangerous misfolded proteins from body fluids. The project intends to establish how the human body defends itself against protein-folding related disease and loss of quality of life. Exposure to everyday physical and chemical stresses can cause proteins to lose their normal shape and become misfolded. Misfolded proteins are causally involved in human ageing and serious diseases (for example, Alzheimer's disease). However, the body does have a protective system that clears dangerous misfolded proteins from body fluids. Using cutting-edge approaches and a novel animal model, the project aims to establish how this system works. The outcomes are expected to improve understanding of the molecular processes affecting human ageing and disease and strengthen the framework needed to develop better strategies to combat these.

Funded Activity Details

Start Date: 16-05-2016

End Date: 31-12-2019

Funding Scheme: Discovery Projects

Funding Amount: $452,800.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking | Animal Cell and Molecular Biology | Biochemistry and Cell Biology | Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified | Neurodegenerative Disorders Related to Ageing | Expanding Knowledge in the Biological Sciences |

Other Keywords

Animal Cell and Molecular Biology | Biochemistry and Cell Biology | Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified | Expanding Knowledge in the Biological Sciences | Neurodegenerative Disorders Related to Ageing | Protein Trafficking | Receptors and Membrane Biology

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