Discovery Projects - Grant ID: DP150104639

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150104639

Funding Status
Closed

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Funded Activity Summary

Complex II proteostasis in mammalian mitochondria. Mitochondria are critical for energy transduction and other metabolic processes in eukaryotic cells. The vast majority of proteins that perform these functions are nuclear-encoded and fold and assemble in the mitochondrion after their import. This project aims to determine the interplay between the dynamic and competing processes of protein complex biogenesis and quality control in the assembly of respiratory complex II. The project aims to determine the steps and molecular components of the assembly pathway, uncover the molecular mechanism of the only known flavinylation factor and to establish the impact of proteases on this pathway. The project is significant because an imbalance in mitochondrial protein homeostasis leads to diseases in humans.

Funded Activity Details

Start Date: 02-02-2015

End Date: 31-12-2019

Funding Scheme: Discovery Projects

Funding Amount: $320,600.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Biochemistry and Cell Biology not elsewhere classified | Expanding Knowledge in the Biological Sciences

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