Discovery Projects - Grant ID: DP150104609

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150104609

Funding Status
Closed

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Funded Activity Summary

Engineering Cyclic Peptides For Oral Bioavailability. The 21st century has become the age of injectable peptide therapeutics. To fully realise their benefits , peptide drugs need to become smaller, cheaper and orally deliverable. Proteins often exhibit potent and selective biological actions through small peptide surfaces. These surfaces have been mimicked in cyclic peptides that are similarly potent and selective. However, cyclic peptides do not have the right properties to be oral drugs. This project aims to re-engineer their surfaces to survive potential degradation in the gut, to permeate membranes and to withstand clearance from blood. The projected outcome of this project is new information and technology for downsizing proteins to small orally bioavailable peptides for therapeutic applications.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2017

Funding Scheme: Discovery Projects

Funding Amount: $503,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Medicinal and Biomolecular Chemistry

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Education and Training not elsewhere classified | Expanding Knowledge in the Biological Sciences |

Other Keywords

Education and Training not elsewhere classified | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Medicinal and Biomolecular Chemistry | Proteins and Peptides

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