Discovery Projects - Grant ID: DP150104495

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150104495

Funding Status
Closed

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Funded Activity Summary

Understanding how cells in the olfactory nerve prevent brain infection. The project hypothesis is that the phagocytic activity of olfactory ensheathing cells (OECs) is the key factor that prevents bacteria from accessing the brain via the olfactory nerve, and allows continuous regeneration of the olfactory nervous system. This project aims to investigate how OECs phagocytose bacteria and debris from degenerating axons in vivo, and determine key molecular mechanisms in the process. Thus, we will characterise an unknown aspect of OEC biology that is neglected in the field. Intended outcomes include a paradigm shift that glial cells, and not circulatory immune cells, are the main defense against microbial invasion of the olfactory nerve. This is relevant for new therapies targeting neural infection/injury and antibiotic usage.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2018

Funding Scheme: Discovery Projects

Funding Amount: $346,551.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Infectious Agents | Central Nervous System | Neurosciences

ANZSRC Socio-Economic Objective (SEO)

Defence not elsewhere classified | Aboriginal and Torres Strait Islander Health - Determinants of Health | Effects of Climate Change and Variability on Australia (excl. Social Impacts) |

Other Keywords

Aboriginal and Torres Strait Islander Health - Determinants of Health | Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Central Nervous System | Defence not elsewhere classified | Effects of Climate Change and Variability on Australia (excl. Social Impacts) | Infectious Agents | Neurosciences

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