Discovery Projects - Grant ID: DP150103503

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150103503

Funding Status
Closed

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Funded Activity Summary

The Role of DNA Methylation in Transcription Factor Activity. Although it is well established that gene expression is closely correlated with DNA methylation, its role in regulating the activity of DNA-binding proteins remains unclear. It has recently been shown that Krüppel-like transcription factors (KLF) have distinct binding preferences for methylated DNA sequences. This project aims to investigate how the activity of transcription factors is dependent upon targeting of methylated DNA by defining the genome-wide set of sites and structural domains critical for binding. It also will explore the functional significance of these sequences using assays that investigate the importance of DNA methylation in KLF mediated cellular reprogramming to the pluripotent state.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2017

Funding Scheme: Discovery Projects

Funding Amount: $428,100.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression (incl. Microarray and other genome-wide approaches) | Biochemistry and Cell Biology | Biochemistry and Cell Biology not elsewhere classified | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Biochemistry and Cell Biology not elsewhere classified | Expanding Knowledge in the Biological Sciences | Gene Expression (incl. Microarray and other genome-wide approaches) | Structural Biology (incl. Macromolecular Modelling)

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