Discovery Projects - Grant ID: DP150103369

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150103369

Funding Status
Closed

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Funded Activity Summary

The effect of Pt binding to CTR1 on Cu homeostasis and cell phenotype. The copper transport protein CTR1 is commonly believed to transport active cisplatin (a platinum-based anticancer agent) into the cell, but this model is inconsistent with the chemical properties of platinum (Pt) and CTR1. The project aims to interrogate the interaction between CTR1 and Pt in cells by developing new chemical tools for the study of Pt species within cells. It will then study the effect of the CTR1-Pt interaction on copper homeostasis and cell phenotype. It is expected that the results will provide valuable information on the status of CTR1 and Pt following interaction, and reveal whether less toxic complexes are just as effective in decreasing cell malignancy as cisplatin itself.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2017

Funding Scheme: Discovery Projects

Funding Amount: $320,500.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Chemotherapy | Inorganic Chemistry | Bioinorganic Chemistry | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Cancer and Related Disorders |

Other Keywords

Bioinorganic Chemistry | Biologically Active Molecules | Cancer and Related Disorders | Chemotherapy | Expanding Knowledge in the Chemical Sciences | Inorganic Chemistry

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