Discovery Projects - Grant ID: DP150103231

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150103231

Funding Status
Closed

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Funded Activity Summary

Use of quinone adducted peptides in the regulation of fertility. This project describes a novel strategy for the non-surgical induction of sterility in male and female mammals with applications in the fields of biotechnology, veterinary medicine and the humane control of pest animal species. The approach is dependent upon the known sensitivity of the germ line to oxidative stress. The strategy rests upon the demonstration that quinone-adducted peptides will selectively bind to non-renewable cell types in the ovary and testis and redox cycle at the cell surface generating a highly localised state of oxidative stress. This stress will then recapitulate the impact of radiation on reproductive tissues by selectively compromising the viability of the germ line, inducing a state of sterility.

Funded Activity Details

Start Date: 16-02-2015

End Date: 31-12-2018

Funding Scheme: Discovery Projects

Funding Amount: $403,300.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Reproduction | Humane Animal Treatment | Cell Metabolism | Animal Production

ANZSRC Socio-Economic Objective (SEO)

Environmentally Sustainable Animal Production not elsewhere classified | Control of Pests, Diseases and Exotic Species not elsewhere classified | Veterinary Pharmaceutical Products not elsewhere classified |

Other Keywords

Animal Production | Animal Reproduction | Cell Metabolism | Control of Pests, Diseases and Exotic Species not elsewhere classified | Environmentally Sustainable Animal Production not elsewhere classified | Humane Animal Treatment | Veterinary Pharmaceutical Products not elsewhere classified

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