Discovery Projects - Grant ID: DP150102587

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150102587

Funding Status
Closed

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Funded Activity Summary

Understanding the Cellular Pathways of Nuclear Receptor Activation. The success of drug treatment depends critically on specificity, i.e., stimulation of a therapeutic response at a target site, and avoidance of activity at other (potentially toxic) locations. This project aims to explore how drug interactions with binding proteins in the cytosol can induce nuclear transport and tissue specific activation of nuclear receptors - a major drug target. The project intends to employ molecular, structural and cell biology approaches to map drug-binding protein-receptor interactions and to determine how the structure of these complexes dictates receptor activation. The data could provide a roadmap to design drugs that interact with the right protein in the right tissue and in doing so dramatically enhance drug specificity.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2019

Funding Scheme: Discovery Projects

Funding Amount: $563,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences | Pharmaceutical Sciences |

ANZSRC Socio-Economic Objective (SEO)

Human Pharmaceutical Treatments (e.g. Antibiotics)

Other Keywords

Human Pharmaceutical Treatments (e.g. Antibiotics) | Pharmaceutical Sciences | Pharmacology and Pharmaceutical Sciences

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