Discovery Projects - Grant ID: DP150102287

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150102287

Funding Status
Closed

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Funded Activity Summary

Unraveling autotransporter function in bacterial aggregates and biofilms. Autotransporters are a large family of bacterial proteins that play a central role in pathogenesis. They promote the formation of cell clusters and biofilms, which are mechanisms for bacterial resistance to host immune factors and antibiotics. Currently, the precise mode of action of autotransporters is unknown. This project will examine the interplay between the structure and function of key autotransporter proteins. It is expected that the outcomes of this research will establish how these proteins mediate aggregation and biofilm formation. It may also provide three-dimensional structures of proteins that are strongly immunogenic and may represent targets for future vaccine design, as well as identify molecules that inhibit autotransporter function.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2017

Funding Scheme: Discovery Projects

Funding Amount: $333,400.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling) | Microbiology | Microbiology not elsewhere classified | Bacteriology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Infectious Diseases |

Other Keywords

Bacteriology | Expanding Knowledge in the Biological Sciences | Infectious Diseases | Microbiology | Microbiology not elsewhere classified | Structural Biology (incl. Macromolecular Modelling)

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