Discovery Projects - Grant ID: DP150102153

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150102153

Funding Status
Closed

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Funded Activity Summary

Elucidating the post-transcriptional regulation of mast cell proteases. Mast cells (MCs) are immune cells that protect against pathogens but may induce deleterious inflammation. MC function is mediated by specific proteases that are pre-formed and stored in granules. These proteases have unique yet poorly understood mechanisms of regulation. The aim of the project is to use a novel suite of molecular tools and genetically modified mice to identify the critical regions of transcripts that post-transcriptionally regulate the production and storage of these proteins. The project aims to identify the RNA binding proteins, microRNAs and other novel factors that also regulate them. This is expected to elucidate the post-transcriptional mechanisms of regulation of MC proteases.

Funded Activity Details

Start Date: 30-06-2015

End Date: 31-12-2018

Funding Scheme: Discovery Projects

Funding Amount: $443,900.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology | Respiratory Diseases | Cardiorespiratory Medicine and Haematology | Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

Respiratory System and Diseases (incl. Asthma) | Immune System and Allergy |

Other Keywords

Cardiorespiratory Medicine and Haematology | Cellular Immunology | Immune System and Allergy | Innate Immunity | Respiratory Diseases | Respiratory System and Diseases (incl. Asthma)

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