Discovery Projects - Grant ID: DP150101929

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150101929

Funding Status
Closed

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Funded Activity Summary

Assembly and stability of human voltage-gated potassium channels. The Kv11.1 voltage-gated potassium channel is an important regulator of cardiac function and a problem for the pharmaceutical industry due to its promiscuity with respect to drug binding. This project aims to investigate how Kv11.1 channels fold and assemble into tetramers and what stabilizes them in the cell membrane. Borrowing from insights gained from the structural analysis of G-Protein coupled receptors, the project intends to apply a novel protein stabilization strategy to facilitate the structural analysis of Kv11.1 channels. The successful completion of the project could reveal important insights into how these molecular machines work as well as enable atomic level studies of how drugs interact and bind to these channels.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-01-2018

Funding Scheme: Discovery Projects

Funding Amount: $420,236.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking | Biochemistry and Cell Biology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling) |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Medical and Health Sciences | Protein Trafficking | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

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