Discovery Projects - Grant ID: DP150101425

Funded Activity Summary

Exploitation of unusual patterns of reactivity of peptides towards radicals. Life depends on free radical reactions of peptides and proteins but, for these compounds to exist, these must be inherently resistant to radicals. This project aims to combine state-of-the-art experiment and theoretical computations to build a detailed picture of peptide and protein radical reactivity, in order to explain this paradox and resolve ambiguities regarding processes through which radical damage to peptides occurs and is repaired. The project also aims to critically evaluate the basic concept of the fidelity of amino acid incorporation during protein biosynthesis. The results of this project could underpin the development of new strategies and therapeutics to treat human diseases, and new materials and synthetic methods to increase the utility of peptides in biotechnology.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2020

Funding Scheme: Discovery Projects

Funding Amount: $843,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Physical Organic Chemistry | Reaction Kinetics and Dynamics | Organic Chemistry | Organic Chemical Synthesis

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Manufacturing not elsewhere classified |

Other Keywords

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Manufacturing not elsewhere classified | Organic Chemical Synthesis | Organic Chemistry | Physical Organic Chemistry | Reaction Kinetics and Dynamics

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