Discovery Projects - Grant ID: DP150101112

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150101112

Funding Status
Closed

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Funded Activity Summary

Lipid-protein interplay in the mechanism of the sodium pump. The sodium pump is the major energy-consuming enzyme of animal cells. Its ion pumping is essential to numerous physiological processes (e.g. nerve, muscle and kidney activity and the maintenance of cell volume). Because of its importance in so many cell functions, the enzyme must be able to respond to cellular conditions. Using measurements of the enzyme's activity in isolated membrane fragments and comparison with its behaviour in living cells, this project aims to determine how sodium pump activity is modulated by transmembrane electric potential and intramembrane electric field strength. Our project could provide fundamental new knowledge on how membrane protein function in general can be controlled by electrical properties of their lipid surroundings.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2017

Funding Scheme: Discovery Projects

Funding Amount: $340,300.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Physiology - Biophysics | Enzymes | Biochemistry and Cell Biology | Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular System and Diseases | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Animal Physiology - Biophysics | Biochemistry and Cell Biology | Cardiovascular System and Diseases | Enzymes | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Receptors and Membrane Biology

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