Discovery Projects - Grant ID: DP150100936

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150100936

Funding Status
Closed

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Funded Activity Summary

Developing orthogonal synthetic signaling cascades. This project proposes a generic approach for the construction of molecular switches based on artificially autoinhibited proteases. The bottom-up design of protein-based signaling networks is a key goal of synthetic biology. Yet, this remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Using structure-guided design and directed protein evolution, a set of protease-based signal transducers and ligand activated allosteric receptors will be created. The developed components are intended to be used to construct artificial signaling networks in mammalian cells that are orthogonal to the endogenous signaling cascades.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2018

Funding Scheme: Discovery Projects

Funding Amount: $534,700.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Signal Transduction | Synthetic Biology

ANZSRC Socio-Economic Objective (SEO)

Industrial Instruments | Medical Instruments | Human Diagnostics |

Other Keywords

Biochemistry and Cell Biology | Enzymes | Human Diagnostics | Industrial Instruments | Medical Instruments | Signal Transduction | Synthetic Biology

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