Discovery Projects - Grant ID: DP150100505

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP150100505

Funding Status
Closed

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Funded Activity Summary

Structural basis for the assembly of caveolae. Caveolae are small invaginations of the plasma membrane and are a characteristic feature of eukaryotic cells. Described morphologically in the early 1950s their many important functions are only just beginning to be revealed. Caveolae are multifunctional organelles that play a vital role in normal cellular processes such as signalling and membrane homeostasis, and are perturbed in cancer, lipid storage and muscle diseases. A new family of coat proteins called cavins have recently been discovered. Cavins are essential for the formation of caveolae, and this project seeks to understand how these multiprotein complexes are assembled at the membrane interface and control caveola function at the molecular level.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2018

Funding Scheme: Discovery Projects

Funding Amount: $507,800.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Protein Trafficking | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Structural Biology (incl. Macromolecular Modelling)

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