Discovery Projects - Grant ID: DP150100383

Funded Activity Summary

Tags and algorithms for studies of protein structures and interactions. This project aims to develop a new set of tools to structurally characterise protein-protein and protein-ligand interactions that are difficult or impossible to analyse by other means, facilitate tracking of proteins in biological material and identify interaction partners. The project seeks to focus on the synthesis of new unnatural amino acids and tags for site-specific protein labelling, and a range of techniques for 3D structure analysis in solution, in particular NMR spectroscopy. New algorithms are expected to be developed for optimizing NMR spectroscopy and structure calculations from sparse data. The integrated set of tools is expected to deliver better and faster structure analysis and target characterisation to accelerate early stages of drug discovery.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2017

Funding Scheme: Discovery Projects

Funding Amount: $483,400.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Chemistry and Spectroscopy | Biochemistry and Cell Biology | Organic Chemical Synthesis | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) |

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) | Organic Chemical Synthesis | Structural Biology (incl. Macromolecular Modelling) | Structural Chemistry and Spectroscopy

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