Discovery Projects - Grant ID: DP140104068

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140104068

Funding Status
Closed

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Funded Activity Summary

Importance of Wzx flippase specificity for O-antigen diversity. The Wzx protein flips subunits of the polysaccharide O antigen (O-units) across the cell membrane on their way to the cell wall. The aim of this project is to determine the specificity that different Wzx flippases have for O unit structure. Previous research has shown that there is much more specificity than previously thought, making Wzx a very interesting protein. Wzx flippases vary enormously in sequence, presumably reflecting the diversity of sugars and linkages in O units. The significance lies in the role of these polysaccharides in interactions with the environment, including host-pathogen interactions and immune responses. The outcome will be a new understanding of the export specificity of O-antigens and also capsules, both of which make very good vaccines.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-03-2017

Funding Scheme: Discovery Projects

Funding Amount: $370,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Agents | Microbial Genetics | Microbiology

ANZSRC Socio-Economic Objective (SEO)

Preventive Medicine | Expanding Knowledge in the Biological Sciences |

Other Keywords

Expanding Knowledge in the Biological Sciences | Infectious Agents | Microbial Genetics | Microbiology | Preventive Medicine

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