Discovery Projects - Grant ID: DP140104059

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140104059

Funding Status
Closed

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Funded Activity Summary

Modelling stem cell decisions in mouse germ cells. A fundamental problem in biology is how cells transition from pluripotency to lineage commitment. The aim of this project is to study this problem, in vivo, by dissecting the mechanisms active during normal development of primordial germ cells (PGCs, gamete stem cells) in the mouse fetal testis. Using molecular, cellular and whole animal assays three central hypotheses will be addressed regarding genes likely to be important in the process. This research will reveal the molecular nature of bipotential switches in cell identity and will inform some of the most important biological issues of our time, including tissue regeneration, aging and cancer biology.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2016

Funding Scheme: Discovery Projects

Funding Amount: $385,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination) | Gene Expression (incl. Microarray and other genome-wide approaches) | Genetics

ANZSRC Socio-Economic Objective (SEO)

Reproductive System and Disorders | Expanding Knowledge in the Biological Sciences |

Other Keywords

Developmental Genetics (incl. Sex Determination) | Expanding Knowledge in the Biological Sciences | Gene Expression (incl. Microarray and other genome-wide approaches) | Genetics | Reproductive System and Disorders

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