Discovery Projects - Grant ID: DP140103743

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140103743

Funding Status
Closed

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Funded Activity Summary

Control of cell fate decisions in neurogenesis: use of embryonic stem cells to investigate key signalling systems and gene expression programs. Human embryonic stem cells (hESC) have the potential to provide an unlimited source of specific subtypes of human neurons for basic studies in neuroscience and biomedical applications. The use of hESC is limited at present by a lack of control over lineage commitment during differentiation in vitro. This project will use engineered reporter hESC lines to investigate which cell signalling pathways and gene expression programs are involved in controlling cell fate. The project will result in improved protocols for hESC differentiation allowing enrichment of cultures with specific neuronal subtypes, and significant advances in the understanding of neuronal lineage commitment and maturation during brain development.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2016

Funding Scheme: Discovery Projects

Funding Amount: $393,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology | Biochemistry and Cell Biology | Signal Transduction | Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Basic Pharmacology | Biochemistry and Cell Biology | Cell Development, Proliferation and Death | Expanding Knowledge in the Biological Sciences | Signal Transduction

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