Discovery Projects - Grant ID: DP140103481

Funding Activity

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Funded Activity Summary

Understanding the role of endogenous siRNAs in the maintenance of genomic defenses. The inappropriate expression of retrotransposons can cause increased genomic instability. The underlying molecular pathways that control retrotransposon expression are not known. This project proposes to investigate this question at a molecular level how naturally occurring small endogenous noncoding RNAs (endo-siRNAs) enforce the epigenetic silencing of retrotransposons and examine the likely impact of endo-siRNAs expression in the packaging and maintenance of retrotransposons. Understanding this fundamental question will advance the scientific knowledge of small RNA functions in our genomic defense systems.

Funded Activity Details

Start Date: 01-04-2014

End Date: 30-06-2016

Funding Scheme: Discovery Projects

Funding Amount: $210,000.00

Funder: Australian Research Council