Discovery Projects - Grant ID: DP140102746

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140102746

Funding Status
Closed

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Funded Activity Summary

Molecular mechanisms for copper trafficking across membranes. Copper is a trace metal that is essential for all forms of life, however it is toxic in excess. Tightly controlled protein-based metalloregulatory systems are responsible for copper uptake and homeostasis in all cells. Components of these systems are integral membrane transport proteins, which include the Ctr proteins that are solely responsible for copper uptake into eukaryotic cells. This project aims to define the molecular mechanisms by which the Ctr proteins transport copper across eukaryotic cell membranes, by solving their three-dimensional structures by X-ray crystallography.

Funded Activity Details

Start Date: 01-01-2014

End Date: 28-02-2017

Funding Scheme: Discovery Projects

Funding Amount: $333,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling) | Bioinorganic Chemistry

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Bioinorganic Chemistry | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

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