Discovery Projects - Grant ID: DP140102318

Funded Activity Summary

Protein-protein interactions in the transcriptional regulation of neural development. Combinations of transcription factor protein regulate the expression of genes, but just how different combinations of these proteins specifically up or down regulate specific genes is poorly understood. This project will focus on the LIM-homeodomain transcription factors, which act in combination to form the so-called "LIM code" that specifies cell type specification during development. Using a series of biophysical and structural approaches. This project will unravel the networks of protein-protein interactions that form the basis of the LIM code. This will help address a major issue in the field: How do interactions between transcription factors regulate DNA-binding specificity. Ultimately, this work may also lead to regeneration of nerve tissue.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2016

Funding Scheme: Discovery Projects

Funding Amount: $363,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Cell Development, Proliferation and Death | Expanding Knowledge in the Biological Sciences | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Structural Biology (incl. Macromolecular Modelling)

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