Discovery Projects - Grant ID: DP140102195

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140102195

Funding Status
Closed

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Funded Activity Summary

Novel peptide mimics for the disruption of chemical communication in bacteria. It is now well established that bacteria communicate with each other via small diffusible signalling molecules and coordinate their activities such as biofilm formation, swarming and expression of virulence factors in a coordinated manner. This project will investigate the synthesis of novel organic molecules that have the capacity to disrupt chemical communication in bacteria. This could allow control of the unwanted microbial activity without the use of growth inhibitory agents such as antibiotics, preservatives and disinfectants that select for the resistant organisms. This elegant approach to eradicating the virulence behaviour of microbes represents a novel strategy to combat antimicrobial resistance.

Funded Activity Details

Start Date: 01-01-2014

End Date: 30-07-2017

Funding Scheme: Discovery Projects

Funding Amount: $390,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medicinal and Biomolecular Chemistry | Biologically Active Molecules | Organic Chemistry not elsewhere classified | Bacteriology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Infectious Diseases |

Other Keywords

Bacteriology | Biologically Active Molecules | Expanding Knowledge in the Chemical Sciences | Infectious Diseases | Medicinal and Biomolecular Chemistry | Organic Chemistry not elsewhere classified

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