Discovery Projects - Grant ID: DP140101574

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140101574

Funding Status
Closed

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Funded Activity Summary

Novel platinum(IV) complexes that are targeted to and trapped by tumours and tumour cells. Platinum complexes continue to be a mainstay in the treatment of solid tumours and their combination with molecularly targeted agents selected for the type of tumour and the mutations identified is expected to lead to continued growth in their use. However, their toxicity remains a major impediment to their use and effectiveness and therefore, this project aims to develop less toxic analogues that are as least as effective as current drugs. This project will combine recent developments in stabilisation and cellular trapping of platinum(IV) pro-drugs with a range of strategies designed to limit activation of these pro-drugs to the tumour environment.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2017

Funding Scheme: Discovery Projects

Funding Amount: $450,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Therapy (excl. Chemotherapy and Radiation Therapy) | Oncology and Carcinogenesis | Bioinorganic Chemistry | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Cancer and Related Disorders |

Other Keywords

Bioinorganic Chemistry | Biologically Active Molecules | Cancer Therapy (excl. Chemotherapy and Radiation Therapy) | Cancer and Related Disorders | Expanding Knowledge in the Chemical Sciences | Oncology and Carcinogenesis

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