Discovery Projects - Grant ID: DP140101461

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140101461

Funding Status
Closed

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Funded Activity Summary

Cholesterol and Hydroxycholesterol Shaping Phagocytosis. Reports now show that membrane cholesterol and 25-hydroxycholesterol (25HC) are required for immune cells to ingest and kill pathogens by phagocytosis. This project will measure phagocytosis in macrophages with genetically or pharmacologically varied cholesterol and 25HC, to compare and quantify the ingestion of different bacteria, fungi and particles. This project will also address the link between cholesterol synthesis, its storage in lipid bodies and its availability for phagocytosis, based on preliminary data showing such defects in the staggerer mouse model. Notably, cholesterol dysregulation is now a prevalent condition in society and our results will reveal at a fundamental, molecular level how this might compromise immune defenses.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2016

Funding Scheme: Discovery Projects

Funding Amount: $420,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking | Biochemistry and Cell Biology | Cell Metabolism | Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

Diabetes | Expanding Knowledge in the Biological Sciences | Immune System and Allergy |

Other Keywords

Biochemistry and Cell Biology | Cell Metabolism | Diabetes | Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Innate Immunity | Protein Trafficking

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