Discovery Projects - Grant ID: DP140100870

Funding Activity

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Funded Activity Summary

How evolution is constrained by trade-offs between the multiplication and survival of organisms. The negative correlation between reproduction (production of large numbers of progeny) and survival (resistance to external challenges) is a crucial trade-off that limits the evolution of perfect organisms. Such trade-offs are extremely difficult to study in closely controlled experiments because of the complexities in biological organisation and life-cycles. This project will explore trade-offs using a novel synthetic biology strategy. Genes in bacteria will be engineered to produce strains with a range of fixed but different trade-off settings. The strain sets will allow unprecedented analysis of reproduction-survival trade-offs and testing of important models of how trade-offs control fitness and evolutionary outcomes.

Funded Activity Details

Start Date: 01-02-2014

End Date: 01-03-2017

Funding Scheme: Discovery Projects

Funding Amount: $342,000.00

Funder: Australian Research Council