Discovery Projects - Grant ID: DP140100485

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140100485

Funding Status
Closed

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Funded Activity Summary

Deciphering the cellular functions of caveolae that govern lymphatic vascular development. Lymphatic vessels play crucial roles in tissue fluid homeostasis, immunity, and fatty acid transport. Despite our recent understanding of genetic pathways that modulate lymphatic cell fate specification, how cellular changes mediate morphogenesis of the lymphatic tree remains to be elucidated. This study will combine cell biology and developmental genetics approaches using mouse and zebrafish transgenic lines that label lymphatic endothelial cells to investigate the role of caveolae proteins in the construction of the lymphatic vascular network. This project aims to improve our fundamental understanding of the processes that govern vascular system assembly and will broaden basic knowledge of organ morphogenesis.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2016

Funding Scheme: Discovery Projects

Funding Amount: $405,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Developmental Genetics (incl. Sex Determination) | Animal Physiology - Cell | Genetics

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Animal Physiology - Cell | Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Developmental Genetics (incl. Sex Determination) | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Genetics

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