Discovery Projects - Grant ID: DP140100480

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140100480

Funding Status
Closed

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Funded Activity Summary

Linking immunomodulation and latency in alphaherpesvirus infection. Herpesviruses cause major diseases in humans and all domestic animal species. Latency forms a significant part of the evolutionary success of herpesviruses, by enabling transmission of the virus throughout the lifetime of the host. Our work has shown that an alphaherpesvirus protein can divert the host’s immune response to become more antibody-mediated and less T cell-mediated. This study explores the consequences of this immune diversion, and examines whether this reduced T cell response enables the development of latent infections. Disrupting the virus-host balance by alterations to this conserved viral protein will enable novel approaches to controlling these economically significant viruses.

Funded Activity Details

Start Date: 01-01-2014

End Date: 02-11-2017

Funding Scheme: Discovery Projects

Funding Amount: $370,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Veterinary Sciences | Veterinary Immunology | Veterinary Virology | Animal Protection (Pests and Pathogens)

ANZSRC Socio-Economic Objective (SEO)

Poultry | Eggs | Infectious Diseases |

Other Keywords

Animal Protection (Pests and Pathogens) | Eggs | Infectious Diseases | Poultry | Veterinary Immunology | Veterinary Sciences | Veterinary Virology

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