Discovery Projects - Grant ID: DP140100304

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140100304

Funding Status
Closed

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Funded Activity Summary

New methods for structural biology and drug discovery by nuclear magnetic resonance spectroscopy. Paramagnetic lanthanide tags offer fresh opportunities in structural biology and for rational drug design. Novel nuclear magnetic resonance (NMR) spectroscopy techniques will selectively detect the NMR signals from protein regions marked by paramagnetic lanthanides, accelerating the structure analysis of protein-ligand complexes. New lanthanide tags will bind to phosphoserine and selenocysteine residues site-specifically introduced into proteins. These tags will also enable accurate distance measurements by electron paramagnetic resonance (EPR) spectroscopy in large, biologically important protein systems hitherto not amenable to detailed structural studies and in proteins undergoing conformational changes.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2016

Funding Scheme: Discovery Projects

Funding Amount: $695,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Chemistry and Spectroscopy | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Infectious Diseases

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Infectious Diseases | Structural Biology (incl. Macromolecular Modelling) | Structural Chemistry and Spectroscopy

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