Discovery Projects - Grant ID: DP140100137

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140100137

Funding Status
Closed

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Funded Activity Summary

How the repair of DNA damage is regulated by IGFBP-3, a protein at the crossroads between cell death and survival. This project aims to discover how a protein called IGFBP-3, which is found in essentially all vertebrates, contributes to the repair of damaged DNA, and to the fate of cells after DNA damage. This is important because all cells are thought to suffer DNA damage many times each day, caused by both environmental and internal events. If unrepaired, this damage can permanently affect a cell’s genetic make-up. If successful, this research will reveal which other proteins IGFBP-3 interacts with, and how it acts at the crossroads between cell survival or death. This information will advance fundamental understanding about important cellular processes and might in future be applied to improving the response of some diseases to treatment.

Funded Activity Details

Start Date: 06-03-2014

End Date: 05-03-2017

Funding Scheme: Discovery Projects

Funding Amount: $390,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Biochemistry and Cell Biology | Cell Development, Proliferation and Death | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Proteomics and Intermolecular Interactions (excl. Medical Proteomics)

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