Discovery Projects - Grant ID: DP140100092

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP140100092

Funding Status
Closed

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Funded Activity Summary

Engineered Hydroxamic Acids for Zirconium-89 Positron Emission Tomography (PET) Imaging of Prostate Cancer. Positron emission tomography (PET) using a zirconium-89-ligand complex bound to a prostate-specific membrane antigen is used to detect and monitor prostate cancer. The hydroxamic acid-based ligand bound to zirconium has a high affinity towards iron, which can cause metal exchange in vivo and loss of radiotracer. The project will prepare new ligands with a higher specificity towards zirconium over iron, and measure immuno-PET imaging activity. A second series of macrocyclic zirconium-specific ligands will be prepared to establish the relationship between variable water-lipid solubility and pharmacokinetic properties. The results will increase the capability of immuno-PET for prostate cancer detection and improve survival outcomes.

Funded Activity Details

Start Date: 24-03-2014

End Date: 31-12-2017

Funding Scheme: Discovery Projects

Funding Amount: $370,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Diagnosis | Inorganic Chemistry | Bioinorganic Chemistry | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Cancer and Related Disorders |

Other Keywords

Bioinorganic Chemistry | Biologically Active Molecules | Cancer Diagnosis | Cancer and Related Disorders | Inorganic Chemistry

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