Discovery Projects - Grant ID: DP1096092

Funded Activity Summary

An RNA interference based genetic screen for novel epigenetic modifiers involved in mammalian X inactivation. All the information required to form an adult human is contained in the DNA of the fertilized egg. Development is achieved by a complex orchestration of genes being switched on and off, controlled by proteins called epigenetic modifiers. Sometimes this goes awry, leading to disease. Despite their vital role, only around ten percent of the potential epigenetic modifiers have been characterized in humans, making it impossible to interpret how they work together, or when they fail. We will develop a novel screen-based technology to find hundreds more true epigenetic modifiers. This technology will aid us and other Australian scientists to understand the role of epigenetics in normal development and disease, ultimately leading to better public health.

Funded Activity Details

Start Date: 01-01-2010

End Date: 13-05-2015

Funding Scheme: Discovery Projects

Funding Amount: $597,970.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression | Genetics | Genetic Development (Incl. Sex Determination) | Biotechnology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

Clinical health not specific to particular organs, diseases and conditions | Blood disorders | Cancer and related disorders |

Other Keywords

Biotechnology Not Elsewhere Classified | Blood disorders | Cancer and related disorders | Clinical health not specific to particular organs, diseases and conditions | Gene Expression | Genetic Development (Incl. Sex Determination) | Genetics

Related Links