Discovery Projects - Grant ID: DP1096029

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP1096029

Funding Status
Closed

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Funded Activity Summary

Spotlighting biologically active Iron (Fe) chelators within cells. Anti-cancer drugs that act in ways different from traditional chemotherapeutics offer hope in evading acquired drug resistance. Previously we have studied compounds that can enter cancer cells, bind iron and halt cellular proliferation. However, there are many sources of iron in cells and we do not know from where these iron chelators acquire their iron or how these iron complexes kill cancer cells. We will tackle this problem by attaching light emitting probes to known iron chelators and mapping their location within cells with high resolution fluorescence microscopy. These experiments will spotlight the cellular location of these potential drugs bound to iron for the first time, providing crucial information on their mode of action.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-04-2014

Funding Scheme: Discovery Projects

Funding Amount: $330,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Bioinorganic Chemistry | Inorganic Chemistry | Transition Metal Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Chemical sciences

Other Keywords

Bioinorganic Chemistry | Chemical sciences | Inorganic Chemistry | Transition Metal Chemistry

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