Discovery Projects - Grant ID: DP1095325

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP1095325

Funding Status
Closed

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Funded Activity Summary

Molecular genetic analyses of trinucleotide repeat expansions. Several neuronal diseases like Huntington's disease, Frederick's ataxia and fragile X syndrome are caused by expansion of trinucleotide repeat sequences in the deoxyribonucleic acid (DNA). These diseases show progressive severity in subsequent generations. Here we use a simple plant model with a very similar DNA mutation to study the genetic basis of repeat expansions over several generations across populations. This proposal will improve our mechanistic understanding of genetic diseases in populations. In addition, this proposal is expected to lead to identification of potential targets and technologies that would be of interest to Australian industry.

Funded Activity Details

Start Date: 01-01-2010

End Date: 31-12-2013

Funding Scheme: Discovery Projects

Funding Amount: $360,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression | Genome Structure | Genetics | Genetic Development (Incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Higher education | Biological sciences |

Other Keywords

Biological sciences | Gene Expression | Genetic Development (Incl. Sex Determination) | Genetics | Genome Structure | Higher education | Nervous system and disorders

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