Discovery Projects - Grant ID: DP1094486

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP1094486

Funding Status
Closed

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Funded Activity Summary

Unravelling transthyretin amyloid, bounding ahead using wallabies. Each protein in our body has a unique shape that enables it to function correctly. For unknown reasons, some proteins can change their shape, aggregate with other proteins and stick to the outside of cells of major organs or nerves. This prevents those cells from working properly and results in disease. Transthyretin is a protein that changes shape and aggregates in the heart of most people over the age of 70. The disease is called Senile Systemic Amyloidosis (SSA). It is not known how or why this happens. There is no cure or therapy. This project will use transthyretins from human and wallaby to explore a possible cause of SSA. If our hypothesis is correct, we will propose preventative actions to reduce the incidence of SSA in the future.

Funded Activity Details

Start Date: 01-01-2010

End Date: 31-12-2015

Funding Scheme: Discovery Projects

Funding Amount: $225,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Molecular Evolution | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Analytical Biochemistry

ANZSRC Socio-Economic Objective (SEO)

Health related to ageing |

Other Keywords

Analytical Biochemistry | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Health related to ageing | Molecular Evolution

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