Discovery Projects - Grant ID: DP1093909

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP1093909

Funding Status
Closed

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Funded Activity Summary

Evolution of a protein fold from toxin to physiological regulator: an endogenous potassium channel blocker in humans. A potassium channel blocking peptide employed by sea anemones as a toxic component of their venom is also found in proteins from a number of higher organisms, including man. In most of these proteins the function of this toxin domain is unknown. This project aims to define the structure and function of this domain in a human protein, matrix metalloprotease 23, which has possible roles in prostate and other cancers. Our results will not only be of interest in tracing the structural and functional evolution of this toxin domain but will also provide valuable clues to its role in both the normal physiological function of matrix metalloprotease 23, as well as its potential pathological role in cancer.

Funded Activity Details

Start Date: 01-01-2010

End Date: 31-03-2013

Funding Scheme: Discovery Projects

Funding Amount: $340,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical And Health Sciences Not Elsewhere Classified | Medical Biochemistry: Proteins And Peptides | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology |

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Cancer and related disorders | Biological sciences

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Cancer and related disorders | Medical And Health Sciences Not Elsewhere Classified | Medical Biochemistry: Proteins And Peptides | Treatments (e.g. chemicals, antibiotics)

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