Discovery Projects - Grant ID: DP0985995

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0985995

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

The essence of being an animal: sponge allorecognition and the evolution of individuality. The human genome encodes the ability to recognise self from nonself at the cellular level. In medicine, this innate ability results in the rejection of transplanted (grafted) tissues from unrelated individuals. This project seeks to get to the evolutionary foundation of self-nonself recognition by studying this process in a simple and tractable model - a sponge from the Great Barrier Reef. Like humans, sponges reject cells and tissues derived from another individual. By defining the genetic basis of self-recognition in sponges we reveal the antiquity of this system and the core features of histocompatibility and immunity. Such insights can inform a range of regenerative medical pursuits.

Funded Activity Details

Start Date: 01-01-2009

End Date: 31-03-2015

Funding Scheme: Discovery Projects

Funding Amount: $870,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Invertebrate Biology | Molecular Evolution | Zoology | Ecology And Evolution Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

Living resources (incl. impacts of fishing on non-target species) | Aquaculture |

Other Keywords

Aquaculture | Ecology And Evolution Not Elsewhere Classified | Invertebrate Biology | Living resources (incl. impacts of fishing on non-target species) | Molecular Evolution | Zoology

Related Links