Discovery Projects - Grant ID: DP0985549

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0985549

Funding Status
Closed

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Funded Activity Summary

New fragment-based drug design technology by NMR spectroscopy. A new nuclear magnetic resonance (NMR) spectroscopic strategy will be developed for rapid determination of the structure and binding mode of low-molecular weight compounds bound to target proteins. Structural information obtained in this way will greatly accelerate drug development by fragment-based drug design, and NMR spectroscopy is the only method that can deliver this information in solution at atomic resolution. The impact of the project for pharmaceutical research is further enhanced by extending the range of proteins amenable to NMR analysis by the development of new labelling strategies using stable isotopes, lanthanides and an unnatural amino acid in a state-of-the-art protein production system.

Funded Activity Details

Start Date: 01-01-2009

End Date: 31-12-2012

Funding Scheme: Discovery Projects

Funding Amount: $654,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Structural Chemistry | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology |

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Biological sciences

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Enzymes | Structural Chemistry | Treatments (e.g. chemicals, antibiotics)

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