Discovery Projects - Grant ID: DP0984536

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0984536

Funding Status
Closed

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Funded Activity Summary

Molecular mechanisms of two-component signal transduction in bacteria. The focus of this research is on the protein complexes that transmit signals in bacteria to elicit the desired responses to environmental stimuli. Like many dynamic processes in cells, signaling requires proteins that are flexible and hence resistant to high-resolution structural analysis using crystallography. We will make use of new research infrastructure at the Australian synchrotron and OPAL research reactor to overcome the challenges of flexibility in these systems. The proteins we will study are not found in humans, and hence our research will provide important structural data on potential targets for the design of novel antibiotics to fight bacterial infection.

Funded Activity Details

Start Date: 02-06-2009

End Date: 28-06-2012

Funding Scheme: Discovery Projects

Funding Amount: $420,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Macromolecular and Materials Chemistry | Protein Targeting And Signal Transduction | Characterisation Of Macromolecules | Biophysics

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Chemical sciences | Physical sciences |

Other Keywords

Biological sciences | Biophysics | Characterisation Of Macromolecules | Chemical sciences | Macromolecular and Materials Chemistry | Physical sciences | Protein Targeting And Signal Transduction

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