Discovery Projects - Grant ID: DP0984232

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0984232

Funding Status
Closed

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Funded Activity Summary

How IGFBP-3 improves cancer cell responsiveness to DNA-damaging therapies. A protein called IGFBP-3 can modulate the way cancer cells respond to treatments such as radiotherapy and certain chemotherapy drugs. These therapies, which act by damaging cells' DNA, play an important role in the treatment of many cancers, but their effectiveness is limited by the ability of cells to oppose the treatment by repairing damaged DNA. This project aims to discover how IGFBP-3 acts to change cancer cells' response to treatment, using breast cancer cells growing in culture as a model system. This work has the potential to lead to improvements in the treatment of cancer patients by increasing our understanding of what happens when cancer cells are exposed to radio- or chemotherapy.

Funded Activity Details

Start Date: 21-01-2009

End Date: 21-01-2013

Funding Scheme: Discovery Projects

Funding Amount: $480,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Oncology And Carcinogenesis | Protein Targeting And Signal Transduction | Cell Development (Incl. Cell Division And Apoptosis)

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Cancer and related disorders |

Other Keywords

Biochemistry and Cell Biology | Cancer and related disorders | Cell Development (Incl. Cell Division And Apoptosis) | Oncology And Carcinogenesis | Protein Targeting And Signal Transduction | Treatments (e.g. chemicals, antibiotics)

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