Discovery Projects - Grant ID: DP0879604

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0879604

Funding Status
Closed

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Funded Activity Summary

Phasevarions of Haemophilus influenzae: mechanisms and origins of a novel epigenetic system controlling coordinated random switching in expression of multiple genes. Central to the utilisation of biological information is our ability to identify and interpret DNA sequence information from genomes. In bacteria that cause disease, these investigations can identify key aspects of the infectious process or potential components of vaccines or new targets for antibiotics. Our recent work has identified a new genetic system, the 'phasevarion', that mediates random expression of multiple genes. The proposed research aims to advance our understanding of gene expression at the most basic level, revealing how bacteria generate diverse populations to evade environmental and immune stresses, and facilitating improved interpretation and use of DNA sequences for researchers and industry in this field.

Funded Activity Details

Start Date: 01-01-2008

End Date: 30-06-2011

Funding Scheme: Discovery Projects

Funding Amount: $577,168.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Microbial Genetics | Gene Expression | Genetics

ANZSRC Socio-Economic Objective (SEO)

Infectious diseases | Prevention—biologicals (e.g. vaccines) | Biological sciences |

Other Keywords

Biological sciences | Gene Expression | Genetics | Infectious diseases | Microbial Genetics | Prevention—biologicals (e.g. vaccines)

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