Discovery Projects - Grant ID: DP0878559

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0878559

Funding Status
Closed

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Funded Activity Summary

Cellular response to pro-oxidative myoglobin. The heart is vulnerable to oxidative damage as specialised muscle cells termed myocytes are unable to regenerate. Oxidative damage to myocytes decreases cell viability and in turn heart muscle function. Pro-oxidative forms of the protein myoglobin are present in the heart and may play a role in damaging myocytes. This study will determine whether a series of novel synthetic antioxidants inhibit myoglobin-mediated damage to heart muscle and preserve function. This may lead to new therapies to combat cardiovascular disease and enable ageing Australians to maintain productive and independent lifestyles.

Funded Activity Details

Start Date: 18-02-2008

End Date: 31-12-2010

Funding Scheme: Discovery Projects

Funding Amount: $420,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Diagnostic Applications | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Animal Physiology—Cell

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular system and diseases | Biological sciences |

Other Keywords

Animal Physiology—Cell | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Cardiovascular system and diseases | Diagnostic Applications

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