Discovery Projects - Grant ID: DP0877789

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0877789

Funding Status
Closed

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Funded Activity Summary

Nuclear magnetic resonance (NMR) studies of complex cellular responses: isotopomer sub-spaces, 'lost' ATP and 'tunable' anisotropy. Red blood cells (RBCs) transport oxygen around the body but they have other roles that are mediated by complex interconnecting metabolic pathways that generate myriad metabolites including ATP. A longstanding conundrum is the inability to account for ~60% of ATP turnover in human RBCs. Processes that may consume this 'lost' ATP, include autonomous motion of the cell membrane called 'flickering', and maintenance of the biconcave-disc shape. NMR spectroscopy of quadrupolar nuclei in chiral aligned media, and isotopomer analysis will be used to define the kinetics of metabolism and membrane processes and thus help define the molecular basis of major blood disorders.

Funded Activity Details

Start Date: 01-04-2008

End Date: 01-04-2011

Funding Scheme: Discovery Projects

Funding Amount: $500,500.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Other Physical Sciences | Cell Metabolism | Instruments And Techniques | Biophysics

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Chemical sciences | Physical sciences |

Other Keywords

Biological sciences | Biophysics | Cell Metabolism | Chemical sciences | Instruments And Techniques | Other Physical Sciences | Physical sciences

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