Discovery Projects - Grant ID: DP0774601

Funding Activity

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Funded Activity Summary

RadioGenes2: Modelling complex biomolecular interactions in radiated tumours: Towards understanding the genesis of therapeutic radioresistance. About 45% of bladder cancer patients require radiotherapy or surgery. Radiotherapy has a failure rate of ~50%. Surgery (bladder removal) diminishes quality of life considerably. Modelling complex gene interactions in radiated cancer cells will provide crucial knowledge on the molecular genesis of radiotherapy-resistance of tumours. Our findings will provide: (i) an accurate mathematical/computational model for diagnosing radiosensitivity; (ii) further insights to be applied in the pharmaceutical sector such as the discovery of novel molecular targets that have the potential to increase radiotherapy success ratios; (iii) a holistic modelling technique applicable to a larger diversity of tumours.

Funded Activity Details

Start Date: 01-01-2007

End Date: 11-01-2008

Funding Scheme: Discovery Projects

Funding Amount: $170,000.00

Funder: Australian Research Council