Discovery Projects - Grant ID: DP0774425

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0774425

Funding Status
Closed

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Funded Activity Summary

Microparticles as effectors of microvascular alterations in brain inflammation. Cerebral malaria (CM) kills many children worldwide, but we do not understand why their small blood vessels in the brain become obstructed. We found that tiny elements detached from cell membranes, called microparticles (MP), are dramatically elevated in the blood during CM. Our results strongly suggest that these MP are important in CM development. We have found that some drugs block the release of MP and the stickiness of malaria parasites to blood vessels. Our project will tackle the conditions of MP production and define new drugs to prevent it. It also will explain how the brain becomes affected by high numbers of MP. Our results will cast new light on why the brain functions abnormally when its blood vessels become modified.

Funded Activity Details

Start Date: 01-02-2007

End Date: 31-01-2010

Funding Scheme: Discovery Projects

Funding Amount: $263,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pathology | Systems Physiology | Central Nervous System | Medical Physiology

ANZSRC Socio-Economic Objective (SEO)

Immune system and allergy | Infectious diseases | Nervous system and disorders |

Other Keywords

Central Nervous System | Immune system and allergy | Infectious diseases | Medical Physiology | Nervous system and disorders | Pathology | Systems Physiology

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